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The incidence of breast cancer in Egyptian women is rising; to date, a few susceptibility genes have been identified. p73 protein (also known as p53-like transcription factor or p53-related protein) is one of the ancestors of the tumor suppressor p53 protein, whose gene islocated with in the chromosomalloci1p36;aregionmostfrequentlydeletedin human cancers.As a consequence of sharing same domain architecture with p53; p73 might regulate p53- response genes and induced cell cycle arrest/ apoptosis in response to DNA damage. A commonly studied non-coding polymorphism consisting of a double nucleotide substitutions(G→A)and(C→T)atposition4and14exon2,situatedupstreamoftheinitialAUG regionsofp73.Thisfunctionalconsequenceofp73polymorphismmayserveasasusceptibility markerforhumancancer,buttheresultsareinconsistent.](https://online.pubhtml5.com/wwnf/hobz/files/shot.jpg)
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170 meters in depth, is located in a meteorite impact crater
100 kilometers to the north of the Arctic Circle in northeastern
Russia. An international drilling campaign recovered a sediment
record from the bottom of the lake, which sheds new light on the
climate history of the Arctic over the past 2.8 million years.
See page 315.](https://online.pubhtml5.com/sgfd/oqld/files/shot.jpg)
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